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Guidance for Healthcare Professionals

The non-hormonal, FDA
cleared birth control app

Explore the software application for contraception that’s clinically proven & backed by science.



Clinical effectiveness

NC° Birth Control’s effectiveness and safety have been demonstrated across 10 peer-reviewed clinical studies, including one of the largest analyses of its kind. The real-life effectiveness of the method remains in line with published rates.

References: FDA De Novo DEN170052.

NC° Birth Control Pearl Index

7 out of 100 became pregnant within one year

5 from incorrect use (unprotected intercourse on fertile days)

2 despite perfect use, of which 0.5 result from the app incorrectly identifying a non-fertile day

Overview of NC° Birth Control

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How NC° Birth Control works

The AI-enhanced algorithm behind the app confirms each user’s daily fertility status by analyzing temperature data, menstrual data & optional LH tests. To prevent pregnancy, users agree to abstain or use protection on fertile days.

Overview of NC° Birth Control

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How biomarkers are collected

Wearables track temperature trends during sleep and auto-sync data to the NC° app. 

The Natural Cycles app is compatible with multiple wearable technologies, including our NC° Band.

Patient eligibility

NC° Birth Control may be a good option for those seeking a non-hormonal, non-invasive birth control method.

NC° Birth Control is suitable for those who:

  • Are 18 years or older
  • Agree to use protection or abstain on fertile days
  • Cannot tolerate hormonal contraception
  • Currently use a period tracker or less effective method

NC° Birth Control is certified for use as a contraceptive in the US, Canada, EU, UK, Australia, South Korea, Singapore and Brazil.

Comparison of contraceptive effectiveness data

NC° Birth Control is more effective than calendar-based FABMs and is in the same effectiveness category as the pill.

Natural Cycles App

NC° Birth Control

93% Typical use
98% Perfect use
Typical use
Perfect use
IUD
>99%Typical use
>99%Perfect use
Contraceptive pill
93%Typical use
>99%Perfect use
Natural Cycles°
93%Typical use
98%Perfect use
Male condom
87%Typical use
98%Perfect use
Withdrawal method
80%Typical use
96%Perfect use
Calendar method
88%Typical use
95%Perfect use

Percentage of typical/perfect users who did not get pregnant with the method over one year of use.
Reference: Contraceptive Technology (Table 5-2). 22nd Edition, 2023

FDA Emoji

Prescribe NC° Birth Control via eRx

Write an electronic prescription for NC° Birth Control to give your patients access to a 12-month subscription via Alto Pharmacy, Natural Cycles’ new exclusive partner.

NC Secure

Advanced data protection

As a regulated medical device, the Natural Cycles app is designed to comply with FDA cybersecurity requirements, and uses advanced security protocols to protect data privacy.

Meet the NC° Medical Advisory Board

Backed by research

Our dedicated on-staff Medical & Research Team has published over 20 peer-reviewed studies, advancing our mission to empower women and further the field of female health.

Access educational resources

Download printable resources developed by the Natural Cycles Medical & Science Team.

Prefer printed copies for your clinic?

Easily request free printed brochures, user manuals, and charts delivered to your clinic.

Contact Natural Cycles°

Contact us about potential partnerships or research collaborations, request printed materials, get more information, or access a demo.

Dr. Kerry Krauss

OB-GYN & Senior Medical Advisor for Natural Cycles

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Common questions

Natural Cycles uses a subscription model, available as an annual or monthly plan. Users can purchase their subscription through our website, their app store, and in some pharmacies. All subscriptions includes access to all modes including NC° Birth Control, NC° Plan Pregnancy, NC° Follow Pregnancy and NC° Postpartum.

Please be aware that when prescribing NC° Birth Control, the Annual Plan is the only option that is currently available for insurance reimbursement.

NC° Birth Control is covered by most major health insurance plans in the US, and a written prescription is often required for reimbursement.

Patients should check their health insurance plan’s benefits to see if they require a prescription to get reimbursed. If needed, fill out the dedicated prescription form on the Natural Cycles website here, and give it to the patient.

After the patient purchases the NC° Annual Plan, they can download their receipt from their account to submit with the rest of their documentation for reimbursement.

NC° Birth Control is a non-hormonal, non-invasive contraceptive method that’s FDA Cleared. It may be a option for those who:

  • Are 18 years or older
  • Agree to use protection or abstain on fertile days
  • Cannot tolerate hormonal contraception
  • Currently use a period tracker or less effective method
  • Are looking to prevent pregnancy now, with a view to plan pregnancy in the future

NC° Birth Control is just as effective for users with irregular cycles, but they may be assigned more fertile days, which may reduce satisfaction. Note that patients cannot use NC° Birth Control at the same time as hormonal contraception.

NC° Birth Control is the first and only contraceptive app to be FDA Cleared and CE marked. As such, the Natural Cycles app is a regulated medical device.

The AI-enhanced algorithm uses body temperature and other fertility indicators to confirm each user’s daily fertility status. Peer-reviewed research found that the algorithm finds fertile days more accurately than calendar-based methods (specifically, the Rhythm Method and Standard Days Method), and that it is less likely to incorrectly assign a non-fertile day. Read more about this research here.

Data security is a top priority for Natural Cycles and NC° Birth Control is designed to protect user data. Natural Cycles Data Protection Officer and Team use advanced security protocols, including pseudonymization and encryption, as part of our comprehensive privacy program.

Users who need an extra layer of identity protection have the option to Go Anonymous. In this optional mode, personal identifying information is separated from fertility data. That means that no one — not even Natural Cycles — can link a user to their data.

Because Natural Cycles charges a subscription fee, it doesn’t need to earn money by selling users’ data like some “free” apps. As a regulated medical device, Natural Cycles is required to comply with the FDA’s cybersecurity requirements. And as a Swedish company, the Natural Cycles app is designed to comply with European GDPR.